Most pears are deciduous, but one or two species in Southeast Asia are evergreen. The French names of pears grown in English medieval gardens suggest that their reputation, at the least, was French; a favored variety in the accounts was named for Saint Rule or Regul', Bishop of Senlis.[9]. caucasica), widely distributed throughout Europe, and sometimes forming part of the natural vegetation of the forests. Pearwood is the favored wood for architect's rulers because it does not warp. Pears are consumed fresh, canned, as juice, and dried. Things are looking up at Pear Therapeutics!The company announced the closure of a $64 million Series C financing barely a month after receiving the thumbs-up from the U.S. Food and Drug Administration (FDA) for reSET-O, its prescription software for the treatment of opioid use-related addiction disorder. Court accounts of Henry III of England record pears shipped from La Rochelle-Normande and presented to the king by the sheriffs of the City of London. The pear is normally propagated by grafting a selected variety onto a rootstock, which may be of a pear or quince variety. Pear wood is close-grained and at least in the past was used as a specialized timber for fine furniture and making the blocks for woodcuts. If it is firm, leave the pear at room temperature and check daily for ripeness. We are leading the development of a new segment in the healthcare industry, prescription digital therapeutics, or PDTs. It is a medium-sized tree, reaching 10–17 m (33–56 ft) tall, often with a tall, narrow crown; a few species are shrubby. Because pears ripen from the inside out, the best way to judge ripeness is to "check the neck": apply gentle thumb pressure to the neck or stem end of the pear. Lincoln[26] describes it as "a fairly tough, very stable wood... (used for) carving... brushbacks, umbrella handles, measuring instruments such as set squares and T-squares... recorders... violin and guitar fingerboards and piano keys... decorative veneering." This verse is repeated twelve times in the song. The word "pear", or its equivalent, occurs in all the Celtic languages, while in Slavic and other dialects, differing appellations, still referring to the same thing, are found—a diversity and multiplicity of nomenclature, which led Alphonse Pyramus de Candolle to infer a very ancient cultivation of the tree from the shores of the Caspian to those of the Atlantic. In a 100 g reference amount, raw pear supplies 57 kilocalories, a moderate amount of dietary fiber, and no other essential nutrients in significant amounts (table). Other species are used as rootstocks for European and Asian pears and as ornamental trees. Pears grow in the sublime orchard of Alcinous, in Odyssey vii: "Therein grow trees, tall and luxuriant, pears and pomegranates and apple-trees with their bright fruit, and sweet figs, and luxuriant olives. Pear is a leader in developing prescription digital therapeutics, gaining the first FDA clearance, in September 2017, for a software application with a safety and efficacy label to treat patients. Salaries posted anonymously by Pear Therapeutics employees. Novartis invested in Pear's Series B round of financing announced in January 2018. communis cultivated mainly in Europe and North America, the Chinese white pear (bai li) Pyrus × bretschneideri, and the Nashi pear Pyrus pyrifolia (also known as Asian pear or apple pear), both grown mainly in eastern Asia. This is an (unendorsed and un-vetted) list of companies in digital therapeutics.Digital therapeutics (DTx) deliver evidence-based therapeutic interventions to patients that are driven by high quality software programs to prevent, manage, or treat a broad spectrum of physical, mental, and behavioral conditions. [citation needed] The enormous number of varieties of the cultivated European pear (Pyrus communis subsp. The pear is native to coastal and mildly temperate regions of the Old World, from Western Europe and North Africa east across Asia. pyraster and P. c. subsp. Many traces have been found in prehistoric pile dwellings around Lake Zurich. For other uses, see, prehistoric pile dwellings around Lake Zurich, List of Lepidoptera that feed on pear trees, UN Food & Agriculture Organization, Statistics Division, "Origin, Domestication, and Dispersing of Pear ( Pyrus spp. BlackThorn Therapeutics is a clinical-stage biopharmaceutical company developing novel, targeted treatments for neurobehavioral disorders. He has served as a director or advisor to several companies, including Gridline Communications Holdings, Pear Therapeutics… Three species account for the vast majority of edible fruit production, the European pear Pyrus communis subsp. Fermented pear juice is called perry or pear cider and is made in a way that is similar to how cider is made from apples. Most are cold-hardy, withstanding temperatures as low as −25 to −40 °C (−13 to −40 °F) in winter, except for the evergreen species, which only tolerate temperatures down to about −15 °C (5 °F). Pear wood is one of the preferred materials in the manufacture of high-quality woodwind instruments and furniture. Pear Therapeutics on Wikipedia, Google News & Yahoo Finance. Health Care. INDUSTRY. Pearl Therapeutics serves customers in the United States. The Willow-leaved pear (Pyrus salicifolia) is grown for its attractive, slender, densely silvery-hairy leaves. The Bradford pear (Pyrus calleryana 'Bradford') in particular has become widespread in North America, and is used only as an ornamental tree, as well as a blight-resistant rootstock for Pyrus communis fruit orchards. Pear Therapeutics highlighted data today from two studies of a digital cognitive behavioral therapy that acted as the precursor for Somryst, the prescription digital therapeutic for adults with chronic insomnia that was the first to pass through the FDA's Pre-Cert pilot pathway. Pearl Therapeutics is a privately held company developing inhaled combination therapies for the treatment of highly prevalent respiratory diseases, including chronic obstructive pulmonary disease and asthma. Learn more. Every day, we push the boundaries of technology to transform medicine. Pear Therapeutics director outlines challenges of regulated software design MobiHealthNews 4/04/19 Pharma Giants Like Novartis and Sanofi Are Betting That The Futre of Healthcare Looks More Like an App or Sensor Than a Prescription Business Insider 2/20/19 Ripening is accelerated by the gas ethylene. A free inside look at company reviews and salaries posted anonymously by employees. Pear and walnut trees were held to be the sacred abodes of beneficent spirits in pre-Islamic Chechen religion and, for this reason, it was forbidden to fell them. The pear tree was an object of particular veneration (as was the Walnut) in the Tree worship of the Nakh peoples of the North Caucasus – see Vainakh mythology and see also Ingushetia – the best-known of the Vainakh peoples today being the Chechens of Chechnya. Disclaimer ADDRESS. [6] Pliny's Natural History recommended stewing them with honey and noted three dozen varieties. Other small-fruited pears, distinguished by their early ripening and apple-like fruit, may be referred to as P. cordata, a species found wild in western France and southwestern England. Pear has a pipeline of products and product candidates across therapeutic areas, including severe psychiatric and neurologic conditions. According to Pear Bureau Northwest, about 3000 known varieties of pears are grown worldwide. A species grown in western China, P. sinkiangensis, and P. pashia, grown in southern China and south Asia, are also produced to a lesser degree. The Registered Agent on file for this company is C T Corporation System and is located at 818 West Seventh St … For new varieties the flowers can be cross-bred to preserve or combine desirable traits. The company's platform combines novel digital interventions with drugs to enhance efficacy well beyond anything that is commercially available or in clinical development, enabling clients to United Therapeutics was founded in 1996 by Martine Rothblatt, an American lawyer, author, and entrepreneur, who created Sirius XM.In 1994, Rothblatt's young daughter was diagnosed with a fatal orphan disease, pulmonary arterial hypertension (PAH). He plays a leadership role in the family-owned Hearst Corporation, one of America's largest diversified media companies where he has been a member of the board of directors since 1990. The pear tree and shrub are a species of genus Pyrus /ˈpaɪrəs/, in the family Rosaceae, bearing the pomaceous fruit of the same name. Quince rootstocks produce smaller trees, which is often desirable in commercial orchards or domestic gardens. And perhaps more surprisingly, they are pulling it off! 'A Partridge in a Pear Tree' is the first gift in "The Twelve Days of Christmas" cumulative song. Pear Therapeutics, Inc. is a California Foreign Corporation filed on January 14, 2016. 08/21/2006. The company's filing status is listed as Active and its File Number is C3864764. Ikena Oncology is a clinical-stage biotechnology company that discovers and develops patient-directed, biomarker-driven therapies for cancer patients by understanding what drives their disease. [24], The culinary or cooking pear is green but dry and hard, and only edible after several hours of cooking. Technology. Rothblatt sold her telecom stock and started the $3 million PPH Cure Foundation to fund PAH research. Two Dutch cultivars are "Gieser Wildeman [nl]" (a sweet variety) and "Saint Remy (pear) [nl]" (slightly sour). Pear Therapeutics Announces FDA Submission for Somryst™, a Prescription Digital Therapeutic for the Treatment of Adults With Chronic Insomnia and Depression - Pear Therapeutics. Pears may be stored at room temperature until ripe. [23] Refrigeration will slow further ripening. If pears are placed next to bananas in a fruit bowl, the ethylene emitted by the banana causes the pears to ripen. Summer and autumn cultivars of Pyrus communis, being climacteric fruits, are gathered before they are fully ripe, while they are still green, but snap off when lifted. CEO and President Dr. Corey McCann said that Somryst, a digital treatment for chronic insomnia and depression, is the first software as a medical device product to be submitted through the regulator's pilot pathway. Pear Therapeutics is a provider of a software-based digital therapeutics platform designed to treat disease and enhance the efficacy of pharmaceuticals. Pear Therapeutics discovers, develops, and delivers clinically-validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. Pears and apples cannot always be distinguished by the form of the fruit;[3] some pears look very much like some apples, e.g. History. PEAR Therapeutics is the leader in FDA-cleared prescription digital therapeutics. The idea is that software can improve a person’s health, without the … Zack is the founder and Chairman of the Neurotechnology Industry Organization, a global trade association representing companies involved in neuroscience, brain research institutes and… The juice can also be used in jellies and jams, usually in combination with other fruits, including berries. The Manchurian or Ussurian Pear, Pyrus ussuriensis (which produces unpalatable fruit) has been crossed with Pyrus communis to breed hardier pear cultivars. Pear is a place for pioneers: for those with a passion for investigating unchartered territories and boldly advancing medicine and patient treatments. The pear was also cultivated by the Romans, who ate the fruits raw or cooked, just like apples. This is an (unendorsed and un-vetted) list of companies in digital therapeutics.Digital therapeutics (DTx) deliver evidence-based therapeutic interventions to patients that are driven by high quality software programs to prevent, manage, or treat a broad spectrum of physical, mental, and behavioral conditions. Pear Therapeutics' digital insomnia therapeutic will put FDA's PreCert framework through its paces. Pearl Therapeutics | 3,727 followers on LinkedIn. … About Pearl Therapeutics. Pear Therapeutics discovers, develops, and delivers clinically-validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. Pears were cultivated in China as early as 2000 BC. The first gathering will come into eating last, and thus the season of the fruit may be considerably prolonged. Health Care. The company combines pharmaceutical therapy with software technology, such as digital applications and games. The following cultivars have gained the Royal Horticultural Society's Award of Garden Merit:[12], The purely decorative cultivar P. salicifolia ‘Pendula’, with pendulous branches and silvery leaves, has also won the award.[20]. The Pearl is a novella by the American author John Steinbeck.The story, first published in 1947, follows a pearl diver, Kino, and explores man's nature as well as greed, defiance of societal norms, and evil.Steinbeck's inspiration was a Mexican folk tale from La Paz, Baja California Sur, Mexico, which he had heard in a visit to the formerly pearl-rich region in 1940. Several species of pears are valued for their edible fruit and juices, while others are cultivated as trees. SECTOR. DevPro Biopharma is a Clinical Research and Development Accelerator with the mission to design, develop, and deliver molecules into medicine. A certain race of pears, with white down on the undersurface of their leaves, is supposed to have originated from P. nivalis, and their fruit is chiefly used in France in the manufacture of perry (see also cider). Stephen Kennedy Smith is a principal at Park Agency – Joseph P. Kennedy Enterprises, the Kennedy family office, and an Investor and Entrepreneur. It is similar to the wood of its relative, the apple tree (Malus domestica) and used for many of the same purposes.[26]. Raw pear is 84% water, 15% carbohydrates and contains negligible protein and fat (table). In 2018, world production of pears was 23.7 million tonnes, led by China with 68% of the total (table). [22] Pears are ripe when the flesh around the stem gives to gentle pressure. The adjective pyriform or piriform means pear-shaped. The genus is thought to have originated in present-day Western China[8] in the foothills of the Tian Shan, a mountain range of Central Asia, and to have spread to the north and south along mountain chains, evolving into a diverse group of over 20 widely recognized primary species. Pear Therapeutics on LinkedIn, Twitter & YouTube. [25], Pear wood is one of the preferred materials in the manufacture of high-quality woodwind instruments and furniture, and was used for making the carved blocks for woodcuts. Pears are fruits produced and consumed around the world, growing on a tree and harvested in late Summer into October. Exercise, dietary management, and the use of drugs, surgery, and psychotherapy are examples of therapeutic measures integral to disease prevention and treatment. Our cross-functional team operates at the … Signs of the disorder include a strong desire to use opioids, increased tolerance to opioids, difficulty fulfilling obligations, trouble reducing use, and withdrawal symptoms with discontinuation. [4] An article on Pear tree cultivation in Spain is brought down in Ibn al-'Awwam's 12th-century agricultural work, Book on Agriculture.[5]. Opioid use disorder (OUD) is a substance use disorder relating to the use of an opioid.Any such disorder causes significant impairment or distress. There are thousands of cultivars of these three species. If it yields to gentle pressure, then the pear is ripe, sweet, and juicy. Pear Therapeutics Announces FDA Submission for Somryst™, a Prescription Digital Therapeutic for the Treatment of Adults With Chronic Insomnia and Depression - Pear Therapeutics. Pear wood is valued for kitchen spoons, scoops and stirrers, as it does not contaminate food with color, flavor or smell, and resists warping and splintering despite repeated soaking and drying cycles. Pearl Therapeutics is developing unique dual and triple combination products for the treatment of widely prevalent respiratory diseases, including chronic obstructive pulmonary disease. The Roman cookbook De re coquinaria has a recipe for a spiced, stewed-pear patina, or soufflé.[7]. )", "RHS Plant Selector Pyrus communis 'Beth' (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Concorde' PBR (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Conference' (D) AGM / RHS Gardening", "RHS Plant Selector Pyrus communis 'Joséphine de Malines' (D) AGM / RHS Gardening", "Production of pears in 2018, Crops/Regions/World Regions/Production Quantity by picklists", Canadian Produce Marketing Association > Home Storage Guide for Fresh Fruits & Vegetables, https://en.wikipedia.org/w/index.php?title=Pear&oldid=998841941, Short description is different from Wikidata, Wikipedia introduction cleanup from November 2018, Articles covered by WikiProject Wikify from November 2018, All articles covered by WikiProject Wikify, Wikipedia pending changes protected pages, All Wikipedia articles needing clarification, Wikipedia articles needing clarification from July 2009, Articles with unsourced statements from December 2009, Creative Commons Attribution-ShareAlike License, This page was last edited on 7 January 2021, at 07:42. 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